New Derivatives from Phencyclidine Increase Food and Water Intake in Wistar Rats

Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Phencyclidine (1-(1-phenylcyclohexyl) piperidine, CAS 956-90-1, PCP, I) and its derivatives have shown many pharmacological and behavioral effects. Also, food and water intake of many drugs such as PCP and its analogues have been studied in laboratory animals. In this work, two derivatives (II, III) of phencyclidine were tested for feeding behaviors effects on rats and compared to PCP and vehicle (saline) . The results showed that, both derivatives can increase food and water intake in comparison to the PCP and vehicle (control) groups that have measured 1-12 h for food and 30–180 min for water intake after injection.